A 35 years old male patient with hepatic encephalopathy

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A 35 years old male patient present to the opd with chief complains of altered sensorium,yellow discoloration of sclera, pedal edema since 1 week. 

History of present illness

Patient was apparently asymptomatic 6 years back. Then he developed yellowish discoloration of sclera in 2014 with altered sensorium so he took treatment in hospital in Hyderabad. 

Where he was diagnosed as the chronic liver disease. From then he was on medication. 

Patient has habit of alcohol, so he was adviced not to consume alcohol. 

He stopped the medication and continued drinking alcohol. 

He had fever from 4 days which is subsided on medication. 

History of loose stools since 4 days. 

History of altered Sensorium. 

History of malena, pain abdomen. 

Past history

No history of diabetes, hypertension, asthma, epilepsy. 

History of tuberculosis 15 years back. 

Personal history

Mixed diet

Irregular bowel and bladder movements. 

Loss of appetite. 

Sleep adequate. 

Patient had habit of consuming alcohol since 20 years. Consumes regular 90ml thrice in a day. 

Treatment history

He took medication for liver disease 6 years back and stopped. 

Not allergic to any known drugs. 

General examination

Patient is unconscious, no response to the commands. 

Poor body built and malnourished. 

Jaundice is present

Pedal edema is present

No pallor

No clubbing

No cyanosis

No generalised lymphadenopathy


Vitals :

Temp : Afebrile

BP : 80/60 mm Hg

PR : 105 bpm

RR : 25 cpm

GRBS : 33 mg / dl

SpO2 : 91 % @ RA


Systemic Examination :

Cardiovascular system

Chest wall is bilaterally symmetrical. 

No pericadial bulge.

No visible pulsations. 

S1, S2 heard. No murmurs. 

Respiratory system:

BAE +

Crepts present. 

Per abdomen:

Distended abdomen

Central nervous system:

Patient is unconscious. 

No response to commands. 

INVESTIGATIONS:

ECG:

On 14/12/2021


On 16/12/2021:


















Hemogram:
On 15/12/2021
Haemoglobin:10.1gm/dl
RBC:3.26
Total leucocyte count:13, 800
Neutrophils:86%
Lymphocytes:06%
Eosinophils:02%
Basophils:0%
Monocytes:06%
Platelets:60,000/cumm
Smear:normocytic normochromic anemia with neutrophilic leucocytosis and thrombocytopenia. 

On 16/12/2021

Haemoglobin:11gm/dl
RBC:3.44 lakhs/cumm
Total leucocyte count:24,200
Neutrophils:90%
Lymphocytes:06%
Eosinophils:0%
Basophils:0%
Monocytes:04%
Platelets:86,000/cumm
Smear:normocytic normochromic anemia with neutrophilic leucocytosis and thrombocytopenia.

Blood urea:58mg/dl
Serum electrolytes:

Ascitic fluid amylase:40 IU/l
Ascitic SAAG:
Ascitic fluid for ldh:135 IU/l
Serum creatinine:2.4mg/dl

Liver function test

Provisional diagnosis:
Hepatic encephalopathy secondary to liver failure. 
Chronic liver disease with ascites. 
Hypoglycemia. 
Grade 2 oesophageal varices. 


Treatment:

PLAN OF TREATMENT:
INJ.LASIX 20 MG/IV/BD
TAB.ALDACTONE 50 MG/RT/BD
INJ.25% DEXTROSE 100ML/IV/SOS IF GRBS<60 MG/DL
SYP. LACTULOSE 20 ML/PO/BD
INJ. THIAMINE 1 AMP IN 100 ML NS/IV/TID
GRBS CHECK HOURLY
BP/PR/TEMP CHARTING HOURLY
T. UDILIV 300 MG/ RT/BD
SYP. HEPAMERZ 2 TBSP/RT/BD
T RIFAXIMIN 550 MG /RT/BD
ENEMA 12 TH HOURLY
STRICT I/O CHARTING
INJ.CEFOTAXIME 2G /IV/BD

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